The Brubaker Lab People Publications Contact
People Publications Contact

Translational Systems Immunology of Host-Microbiome Interactions

Case Western Reserve University School of Medicine

The Brubaker Lab takes a cross-cutting transdisciplinary approach to multiple disease applications of our core research areas. We believe that insights gleaned from addressing clinical need and elucidating disease mechanisms in one area will catalyze breakthroughs in others. Our lab has projects in the following disease areas which are constantly evolving through collaboration and emphasis varies over time.

Microbiome Pharmacology

Computational Preclinical Translation Modeling

Systems Immunology

Women's Health And Sex Differences

Contact us for our current efforts.

People

Douglas Brubaker, Ph.D.

Assistant Professor, Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine

Dr. Brubaker obtained his Ph.D. in Systems Biology and Bioinformatics under the supervision of Dr. Mark R. Chance in the Center for Proteomics and Bioinformatics at Case Western Reserve University. As part of the March of Dimes Prematurity Research Center - Ohio Collaborative, his dissertation focussed on network and dynamical systems modeling of signaling networks in preterm birth.

Dr. Brubaker pursued postdoctoral studies with Dr. Douglas Lauffenburger in the Department of Biological Engineering at MIT where he developed computational methods to translate observations from animal models to humans. Dr. Brubaker started as an Assistant Professor in the Weldon School of Biomedical Engineering at Purdue University in Fall 2020.

The Brubaker Lab aims to understand the core mechanisms by which (i) host physiology is regulated by microbiomes and (ii) microbiome ecology and function are regulated by the host. We are a highly collaborative group with current efforts focused on Inflammatory Bowel Diseases, Musculoskeletal Pathologies, Type 2 Diabetes, and Bacterial Vaginosis.

Staff

Smrutiti Jena, Ph.D.

Post Doctoral Research Assistant

Raymond Krajci

Raymond Krajci

Data and Operations Engineer

Graduate Students

Brendan Ball

Alexander Bergendorf

Alexis Heath

Damilola Lawore

Rachel Liu, Pharm.D.

Dalí Nemecio

Jee Hyun Park

Ran Ran

Affiliates

Alison Treichel, M.D.

Dermatology Resident, University Hospitals

Undergraduate Students

Asmi Mukherjee

Grant Williams

Alumni

Reagan Bushok

B.S., Purdue University 2024

Doctoral Student at Tufts University

Maya Frost

B.S., Purdue University 2024

Medical Student at Northwestern University

Javier Muñoz Briones, Ph.D.

Ph.D., Purdue University 2024

Principal Project Statistician at Eli Lilly and Company

Nina Render

M.S., Purdue University 2024

Medical Student at the University of Kentucky

Alan Trinh, M.D.

M.D., Indiana University School of Medicine 2024

Resident at IU School of Medicine

Publications

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Contact

Biomedical Research Building 420
2109 Adelbert Road
Cleveland, OH 44106

[email protected]